LPL Receptor Inhibitors

S1PR1, EC₅₀: 0.39 nM

S1PR2, EC₅₀: >10000 nM

S1PR3, EC₅₀: >1000 nM

S1PR4, EC₅₀: 750 nM

S1PR5, EC₅₀: 0.98 nM

S1PR1, EC₅₀: 1.03 nM

S1PR5, EC₅₀: 8.6 nM

S1PR1, IC₅₀: 6 nM

S1PR3, IC₅₀: 2068 nM

S1PR4, IC₅₀: 1956 nM

S1PR5, IC₅₀: 142 nM

S1PR1, EC₅₀: 13.8 nM

LPA₁ Receptor

S1PR3

S1PR4, IC₅₀: 25 nM

LPA₂ Receptor, IC₅₀: 9 nM

S1PR1, EC₅₀: 12.6-493 nM

LPA₁ Receptor, IC₅₀: 94 nM

LPA₃ Receptor, IC₅₀: 752 nM

LPA₅ Receptor, IC₅₀: 463 nM

S1PR2

S1PR1, EC₅₀: 1.03 nM

S1PR5, EC₅₀: 8.6 nM

S1PR1, EC₅₀: 1 nM

S1PR4, EC₅₀: 2134 nM

S1PR5, EC₅₀: 36 nM
S1PR5, EC₅₀: 228 nM

LPA₂ Receptor, EC₅₀: 3.3 μM

S1PR1, EC₅₀: 0.19 nM

S1PR5, EC₅₀: 32.8 nM

S1PR1, EC₅₀: 1690 nM

S1PR2, EC₅₀: 119 nM

S1PR3, EC₅₀: 1950 nM

S1PR4, EC₅₀: >10 μM

S1PR5, IC₅₀: >10 μM

LPA1 Receptor, IC₅₀: 2.7 nM

S1PR1

LPA1 Receptor, Kd: 1.7-14.5 nM

S1PR4, EC₅₀: 46 nM

LPA1 Receptor, IC₅₀: 0.086 μM

S1PR1, EC₅₀: 19.3 nM (human)

S1PR2, EC₅₀: 313.3 nM (human)

S1PR3, EC₅₀: 131.8 nM (human)

S1PR5, EC₅₀: 20 nM

S1PR1, EC₅₀: 0.27 nM

S1PR5, EC₅₀: 5.9 nM

S1PR1, EC₅₀: 0.39 nM

S1PR2, EC₅₀: >10000 nM

S1PR3, EC₅₀: >1000 nM

S1PR4, EC₅₀: 750 nM

S1PR5, EC₅₀: 0.98 nM

S1PR5

S1PR1

LPA₂ Receptor

S1PR1, EC₅₀: 0.042 μM

S1PR3, EC₅₀: 3.47 μM

S1PR1, IC₅₀: 6.4 nM

S1PR1, EC₅₀: 2.6 nM

S1PR5, EC₅₀: 171 nM